Posted: Jan 27, 2011 9:12 pm
I'd hop on I-10 once you get to Baton Rouge, not much to see on 61 but traffic and stop lights between Baton Rouge and NOLA except for the Zapp's potato chip factory in Gramercy and the andouille sausage place in LaPlace. Once in New Orleans you might want to get a picture in front of the sign marking the end of HWY 61 on Tulane Ave at Broad street, which is also directly in front of the N.O. courthouse and prison complex. I always thought the courthouse, jail, and about 20 bail bonds joints was kind of a fitting terminus for the "blues highway".
North of Baton Rouge, St. Francisville is kind of a cool little town and there are lots of weird old plantations around there. not much else. the angola prison museum is a good trek off of 61 (20 miles I think) but it is pretty cool.
plenty of stuff to do in new orleans, and that's the perfect time to visit. what are you looking to do?